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In 1892, Ellen Swallow Richards called for the "christening of a new science" "oekology" (ecology) in a Boston lecture. This new science included the study of "consumer nutrition" and environmental education. This interdisciplinary branch of science was later specialized into what is currently known as ecology, while the consumer nutrition focus split off and was eventually relabeled as home economics, which provided another avenue for women to study science. Richards helped to form the American Home Economics Association, which published a journal, the Journal of Home Economics, and hosted conferences. Home economics departments were formed at many colleges, especially at land grant institutions. In her work at MIT, Ellen Richards also introduced the first biology course in its history as well as the focus area of sanitary engineering. Women also found opportunities in botany and embryology. In psychology, women earned doctorates but were encouraged to specialize in educational and child psychology and to take jobs in clinical settings, such as hospitals and social welfare agencies. In 1901, Annie Jump Cannon first noticed that it was a star's temperature that was the principal distinguishing feature among different spectra. This led to re-ordering of the ABC types by temperature instead of hydrogen absorption-line strength. Due to Cannon's work, most of the then-existing classes of stars were thrown out as redundant. Afterward, astronomy was left with the seven primary classes recognized today, in order: O, B, A, F, G, K, M; that has since been extended.

Henrietta Swan Leavitt first published her study of variable stars in 1908. This discovery became known as the "period-luminosity relationship" of Cepheid variables. Our picture of the universe was changed forever, largely because of Leavitt's discovery. The accomplishments of Edwin Hubble, renowned American astronomer, were made possible by Leavitt's groundbreaking research and Leavitt's Law. "If Henrietta Leavitt had provided the key to determine the size of the cosmos, then it was Edwin Powell Hubble who inserted it in the lock and provided the observations that allowed it to be turned", wrote David H. and Matthew D.H. Clark in their book Measuring the Cosmos. Hubble often said that Leavitt deserved the Nobel for her work. Gösta Mittag-Leffler of the Swedish Academy of Sciences had begun paperwork on her nomination in 1924, only to learn that she had died of cancer three years earlier (the Nobel prize cannot be awarded posthumously). In 1925, Harvard graduate student Cecilia Payne-Gaposchkin demonstrated for the first time from existing evidence on the spectra of stars that stars were made up almost exclusively of hydrogen and helium, one of the most fundamental theories in stellar astrophysics. Canadian-born Maud Menten worked in the US and Germany. Her most famous work was on enzyme kinetics together with Leonor Michaelis, based on earlier findings of Victor Henri. This resulted in the MichaelisMenten equations. Menten also invented the azo-dye coupling reaction for alkaline phosphatase, which is still used in histochemistry. She characterised bacterial toxins from B. paratyphosus, Streptococcus scarlatina and Salmonella ssp., and conducted the first electrophoretic separation of proteins in 1944. She worked on the properties of hemoglobin, regulation of blood sugar level, and kidney function. World War II brought some new opportunities. The Office of Scientific Research and Development, under Vannevar Bush, began in 1941 to keep a registry of men and women trained in the sciences. Because there was a shortage of workers, some women were able to work in jobs they might not otherwise have accessed. Many women worked on the Manhattan Project or on scientific projects for the United States military services. Women who worked on the Manhattan Project included Leona Woods Marshall, Katharine Way, and Chien-Shiung Wu. It was actually Wu who confirmed Enrico Fermi's hypothesis through her earlier draft that Xe-135 impeded the B reactor from working. The adjustments made would quickly let the project resume its course.