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A closely related question is what counts as a good scientific explanation. In addition to providing predictions about future events, society often takes scientific theories to provide explanations for events that occur regularly or have already occurred. Philosophers have investigated the criteria by which a scientific theory can be said to have successfully explained a phenomenon, as well as what it means to say a scientific theory has explanatory power. One early and influential account of scientific explanation is the deductive-nomological model. It says that a successful scientific explanation must deduce the occurrence of the phenomena in question from a scientific law. This view has been subjected to substantial criticism, resulting in several widely acknowledged counterexamples to the theory. It is especially challenging to characterize what is meant by an explanation when the thing to be explained cannot be deduced from any law because it is a matter of chance, or otherwise cannot be perfectly predicted from what is known. Wesley Salmon developed a model in which a good scientific explanation must be statistically relevant to the outcome to be explained. Others have argued that the key to a good explanation is unifying disparate phenomena or providing a causal mechanism.

=== Justifying science ===

Although it is often taken for granted, it is not at all clear how one can infer the validity of a general statement from a number of specific instances or infer the truth of a theory from a series of successful tests. One approach is to acknowledge that induction cannot achieve certainty, but observing more instances of a general statement can at least make the general statement more probable. So the chicken would be right to conclude from all those mornings that it is likely the farmer will come with food again the next morning, even if it cannot be certain. However, there remain difficult questions about the process of interpreting any given evidence into a probability that the general statement is true. One way out of these particular difficulties is to declare that all beliefs about scientific theories are subjective, or personal, and correct reasoning is merely about how evidence should change one's subjective beliefs over time. Some argue that what scientists do is not inductive reasoning at all but rather abductive reasoning, or inference to the best explanation. In this account, science is not about generalizing specific instances but rather about hypothesizing explanations for what is observed. As discussed in the previous section, it is not always clear what is meant by the "best explanation". Occam's razor, which counsels choosing the simplest available explanation, thus plays an important role in some versions of this approach. To return to the example of the chicken, would it be simpler to suppose that the farmer cares about it and will continue taking care of it indefinitely or that the farmer is fattening it up for slaughter? Philosophers have tried to make this heuristic principle more precise regarding theoretical parsimony or other measures. Yet, although various measures of simplicity have been brought forward as potential candidates, it is generally accepted that there is no such thing as a theory-independent measure of simplicity. In other words, there appear to be as many different measures of simplicity as there are theories themselves, and the task of choosing between measures of simplicity appears to be every bit as problematic as the job of choosing between theories. Nicholas Maxwell has argued for some decades that unity rather than simplicity is the key non-empirical factor in influencing the choice of theory in science, persistent preference for unified theories in effect committing science to the acceptance of a metaphysical thesis concerning unity in nature. In order to improve this problematic thesis, it needs to be represented in the form of a hierarchy of theses, each thesis becoming more insubstantial as one goes up the hierarchy.

=== Observation inseparable from theory ===

When making observations, scientists look through telescopes, study images on electronic screens, record meter readings, and so on. Generally, on a basic level, they can agree on what they see, e.g., the thermometer shows 37.9 degrees C. But, if these scientists have different ideas about the theories that have been developed to explain these basic observations, they may disagree about what they are observing. For example, before Albert Einstein's general theory of relativity, observers would have likely interpreted an image of the Einstein cross as five different objects in space. In light of that theory, however, astronomers will tell you that there are actually only two objects, one in the center and four different images of a second object around the sides. Alternatively, if other scientists suspect that something is wrong with the telescope and only one object is actually being observed, they are operating under yet another theory. Observations that cannot be separated from theoretical interpretation are said to be theory-laden. All observation involves both perception and cognition. That is, one does not make an observation passively, but rather is actively engaged in distinguishing the phenomenon being observed from surrounding sensory data. Therefore, observations are affected by one's underlying understanding of the way in which the world functions, and that understanding may influence what is perceived, noticed, or deemed worthy of consideration. In this sense, it can be argued that all observation is theory-laden.

=== The purpose of science ===