kb/data/en.wikipedia.org/wiki/Sentinel_Initiative-0.md

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---
title: "Sentinel Initiative"
chunk: 1/1
source: "https://en.wikipedia.org/wiki/Sentinel_Initiative"
category: "reference"
tags: "science, encyclopedia"
date_saved: "2026-05-05T12:00:39.968567+00:00"
instance: "kb-cron"
---
Sentinel Initiative is a set of efforts by U.S. Food and Drug Administration (FDA) that tries to improve the ability to identify and evaluate safety of medicinal products.
It has several parts: Sentinel System, Postmarket Rapid Immunization Safety Monitoring (PRISM) system, and Blood Safety Continuous Active Surveillance Network (BloodSCAN). Part of Sentinel Initiative is a surveillance program for biologics. It is called Biologics Effectiveness and Safety (BEST) Initiative.
== Sentinel System ==
The Sentinel System uses pre-existing electronic healthcare data (including billing data). Part of the Sentinel System is a tool called Active Postmarket Risk Identification and Analysis (ARIA) system that was mandated in the U.S. Food and Drug Administration (FDA) Amendments Act (FDAAA) of 2007.
== See also ==
Health informatics
Real world data
Real world evidence
== References ==