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| title | chunk | source | category | tags | date_saved | instance |
|---|---|---|---|---|---|---|
| Neural Darwinism | 5/8 | https://en.wikipedia.org/wiki/Neural_Darwinism | reference | science, encyclopedia | 2026-05-05T08:31:16.671366+00:00 | kb-cron |
== TNGS – the theory of neuronal group selection == Edelman's motivation for developing the theory of neuronal group selection (TNGS) was to resolve "a number of apparent inconsistencies in our knowledge of the development, anatomy, and physiological function of the central nervous system." A pressing issue for Edelman was explaining perceptual categorization without reference to a central observing homunculus or "assuming that the world is prearranged in an informational fashion." To free himself of the demands, requirements, and contradictions of information processing model; Edelman proposes that perceptual categorization operates by the selection of neuronal groups organized into variant networks that are differentially amplified of their responses in conjunction with hedonic feedback over the course of experience, from within a massive population of neuronal groups being confronted by a chaotic array of sensory input of differing degrees of significance and relevance to the organism. Edelman outright rejects the notion of a homunculus, describing it as a "close cousin of the developmental electrician and the neural decoder", artifacts of the observer-centralized top-down design logic of information processing approaches. Edelman properly points out that "it is probably a safe guess that most neurobiologists would view the homunculus as well as dualist solutions (Popper and Eccles 1981) to the problems of subjective report as being beyond scientific consideration."
=== Necessary criteria for a selectionist theory of higher brain function === Edelman's first theoretical contribution to neural Darwinism came in 1978, when he proposed his group selection and phasic reentrant signalling. Edelman lays out five necessary requirements that a biological theory of higher brain function must satisfy.
The theory should be consistent with the fields of embryology, neuroanatomy, and neurophysiology. The theory should account for learning and memory, and temporal recall in a distributed system. The theory should account how memory is updated on the basis of realtime experience. The theory should account for how higher brain systems mediate experience and action. The theory should account for the necessary, if not sufficient, conditions for the emergence of awareness.
=== Organization of the TNGS theory === Neural Darwinism organizes the explanation of TNGS into three parts – somatic selection, epigenetic mechanisms, and global functions. The first two parts are concerned with how variation emerges through the interaction of genetic and epigenetic events at the cellular level in response to events occurring at the level of the developing animal nervous system. The third part attempts to build a temporally coherent model of globally unitary cognitive function and behavior that emerges from the bottom up through the interactions of the neuronal groups in real-time. Edelman organized key ideas of the TNGS theory into three main tenets:
Primary repertoire – developmental formation and selection of neuronal groups; Secondary repertoire – behavioral and experiential selection leading to changes in the strength of connections between synaptic populations that bind together neuronal groups; Reentrant signaling – the synchronous entrainment of reciprocally connected neuronal groups within sensorimotor maps into ensembles of coherent global activity. The primary repertoire is formed during the period from the beginning of neurulation to the end of apoptosis. The secondary repertoire extends over the period synaptogenesis and myelination, but will continue to demonstrate developmental plasticity throughout life, albeit in a diminished fashion compared to early development. The two repertoires deal with the issue of the relationship between genetic and epigenetic processes in determining the overall architecture of the neuroanatomy – seeking to reconcile nature, nurture, and variability in the forming the final phenotype of any individual nervous system. There is no point-to-point wiring that carries a neural code through a computational logic circuit that delivers the result to the brain because
firstly, the evidence does not lend support to such notion in a manner that is not problematic, secondly, the noise in the system is too great for a neural code to be coherent, and third, the genes can only contribute to, and constrain, developmental processes; not determine them in all their details. Variation is the inevitable outcome of developmental dynamics. Reentrant signalling is an attempt to explain how "coherent temporal correlations of the responses of sensory receptor sheets, motor ensembles, and interacting neuronal groups in different brain regions occur".
==== Primary repertoire- developmental selection ==== The first tenet of TNGS concerns events that are embryonic and run up to the neonatal period. This part of the theory attempts to account for the unique anatomical diversification of the brain even between genetically identical individuals. The first tenet proposes the development of a primary repertoire of degenerate neuronal groups with diverse anatomical connections are established via the historical contingencies of the primary processes of development. It seeks to provide an explanation of how the diversity of neuronal group phenotypes emerge from the organism's genotype via genetic and epigenetic influences that manifest themselves mechano-chemically at the cell surface and determine connectivity. Edelman list the following as vital to the formation of the primary repertoire of neuronal groups but, also contributing to their anatomical diversification and variation:
Cell division – there are repeated rounds of cell division in the formation of neuronal populations Cell death – there is extensive amounts of pre-programmed cell death that occurs via apoptosis within the neuronal populations. Process extension and elimination – the exploratory probing of the embryonic environment by developing neurons involve process extension and elimination as the neurons detect molecular gradients on neighboring cell surface membranes and the substrate of the extracellular matrix. CAM & SAM action – the mechanochemistry of cell and surface adhesion molecules plays a key role in the migration and connectivity of neurons as they form neuronal groups within the overall distributed population. Two key questions with respect to this issue that Edelman is seeking to answer "in terms of developmental genetic and epigenetic events" are:
"How does a one-dimensional genetic code specify a three-dimensional animal?" "How is the answer to this question consistent with the possibility of relatively rapid morphological change in relatively short periods of evolutionary time?"