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=== Ancient history === The involvement of women in the field of medicine has been recorded in several early civilizations. An ancient Egyptian physician, Peseshet (c.26002500 B.C.E.), described in an inscription as "lady overseer of the female physicians", is the earliest known female physician named in the history of science. Agamede was cited by Homer as a healer in ancient Greece before the Trojan War (c. 11941184 BCE). The study of natural philosophy in ancient Greece was open to women. Recorded examples include Aglaonike, who predicted eclipses; and Theano, mathematician and physician, who was a pupil (possibly also wife) of Pythagoras, and one of the school in Crotone founded by Pythagoras, which included many other women. A passage in Pollux speaks about those who invented the process of coining money, mentioning Pheidon and Demodike from Cyme, wife of the Phrygian king, Midas, and daughter of King Agamemnon of Cyme. A daughter of a certain Agamemnon, king of Aeolian Cyme, married a Phrygian king called Midas. This link may have facilitated the Greeks "borrowing" their alphabet from the Phrygians because the Phrygian letter shapes are closest to the inscriptions from Aeolis. During the period of the Babylonian civilization, around 1200 BCE, two perfumeresses named Tapputi-Belatekallim and -ninu (first half of her name unknown) were able to obtain the essences from plants by using extraction and distillation procedures. During the Egyptian dynasty, women were involved in applied chemistry, such as the making of beer and the preparation of medicinal compounds. Women have been recorded to have made major contributions to alchemy. Many of whom lived in Alexandria around the 1st or 2nd centuries C.E., where the gnostic tradition led to female contributions being valued. The most famous of the women alchemists, Mary the Jewess, is credited with inventing several chemical instruments, including the double boiler (bain-marie); the improvement or creation of distillation equipment of that time. Such distillation equipment was called kerotakis (simple still) and the tribikos (a complex distillation device). Hypatia of Alexandria (c. 350415 CE), daughter of Theon of Alexandria, was a philosopher, mathematician, and astronomer. She is the earliest female mathematician about whom detailed information has survived. Hypatia is credited with writing several important commentaries on geometry, algebra, and astronomy. Hypatia was the head of a philosophical school and taught many students. In 415 CE, she became entangled in a political dispute between Cyril, the bishop of Alexandria, and Orestes, the Roman governor, which resulted in a mob of Cyril's supporters stripping her, dismembering her, and burning the pieces of her body.

=== Medieval Europe ===

The early parts of the European Middle Ages, also known as the Dark Ages, were marked by the decline of the Roman Empire. The Latin West was left with great difficulties that dramatically affected the continent's intellectual production. Although nature was still seen as a system that could be comprehended through reason, there was little innovative scientific inquiry. The Arabic world deserves credit for preserving scientific advancements. Arabic scholars produced original scholarly work and generated copies of manuscripts from classical periods. During this period, Christianity underwent a period of resurgence, and Western civilization was bolstered as a result. This phenomenon was, in part, due to monasteries and nunneries that nurtured the skills of reading and writing, and the monks and nuns who collected and copied important writings by scholars of the past. As it mentioned before, convents were an important place of education for women during this period, for the monasteries and nunneries encourage the skills of reading and writing, and some of these communities provided opportunities for women to contribute to scholarly research. An example is the German abbess Hildegard of Bingen (10981179 A.D), a famous philosopher and botanist, whose prolific writings include treatments of various scientific subjects, including medicine, botany and natural history (c. 115158). Another famous German abbess was Hroswitha of Gandersheim (9351000 A.D.) that also helped encourage women to be intellectual. However, with the growth in number and power of nunneries, the all-male clerical hierarchy was not welcomed toward it, and thus it stirred up conflict by having backlash against women's advancement. That impacted many religious orders closed on women and disbanded their nunneries, and overall excluding women from the ability to learn to read and write. With that, the world of science became closed off to women, limiting women's influence in science. Entering the 11th century, the first universities emerged. Women were, for the most part, excluded from university education. However, there were some exceptions. The Italian University of Bologna allowed women to attend lectures from its inception, in 1088. The attitude toward educating women in medical fields in Italy appears to have been more liberal than in other places. The physician Trotula di Ruggiero, is supposed to have held a chair at the Medical School of Salerno in the 11th century, where she taught many noble Italian women, a group sometimes referred to as the "ladies of Salerno". Several influential texts on women's medicine, dealing with obstetrics and gynecology, among other topics, are also often attributed to Trotula. Dorotea Bucca was another distinguished Italian physician. She held a chair of philosophy and medicine at the University of Bologna for over forty years, from 1390. Other Italian women whose contributions in medicine have been recorded include Abella, Jacobina Félicie, Alessandra Giliani, Rebecca de Guarna, Margarita, Mercuriade (14th century), Constance Calenda, Calrice di Durisio (15th century), Constanza, Maria Incarnata and Thomasia de Mattio. Despite the success of some women, cultural biases affecting their education and participation in science were prominent in the Middle Ages. For example, Saint Thomas Aquinas, a Christian scholar, wrote, referring to women, "She is mentally incapable of holding a position of authority."

=== Scientific Revolutions of 1600s and 1700s ===