16 lines
1.0 KiB
Markdown
16 lines
1.0 KiB
Markdown
---
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title: "Open-label trial"
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chunk: 1/1
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source: "https://en.wikipedia.org/wiki/Open-label_trial"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T03:44:27.552355+00:00"
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instance: "kb-cron"
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---
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An open-label trial, or open trial, is a type of clinical trial in which information is not withheld from trial participants. In particular, both the researchers and participants know which treatment is being administered. This contrasts with a double-blinded trial, where information is withheld both from the researchers and the participants to reduce bias.
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Open-label trials may be appropriate for comparing two similar treatments to determine which is most effective, such as a comparison of different prescription anticoagulants, or possible relief from symptoms of some disorders when a placebo is given.
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An open-label trial may still be randomized. Open-label trials may also be uncontrolled (without a placebo group), with all participants receiving the same treatment. This would be a single-arm study design.
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== References == |