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| title | chunk | source | category | tags | date_saved | instance |
|---|---|---|---|---|---|---|
| History of genetics | 1/3 | https://en.wikipedia.org/wiki/History_of_genetics | reference | science, encyclopedia | 2026-05-05T03:59:45.663532+00:00 | kb-cron |
The history of genetics dates from the classical era with contributions by Pythagoras, Hippocrates, Aristotle, Epicurus, and others. Modern genetics began with the work of the Augustinian friar Gregor Johann Mendel. His works on pea plants, published in 1866, provided the initial evidence that, on its rediscovery in the 1900s, helped to establish the theory of Mendelian inheritance. In ancient Greece, Hippocrates suggested that all organs of the body of a parent gave off invisible "seeds", miniaturised components that were transmitted during sexual intercourse and combined in the mother's womb to form a baby. In the early modern period, William Harvey's book On Animal Generation contradicted Aristotle's theories of genetics and embryology. The 1900 rediscovery of Mendel's work by Hugo de Vries, Carl Correns and Erich von Tschermak led to rapid advances in genetics. By 1915 the basic principles of Mendelian genetics had been studied in a wide variety of organisms – most notably the fruit fly Drosophila melanogaster. Led by Thomas Hunt Morgan and his fellow "drosophilists", geneticists developed the Mendelian model, which was widely accepted by 1925. Alongside experimental work, mathematicians developed the statistical framework of population genetics, bringing genetic explanations into the study of evolution. With the basic patterns of genetic inheritance established, many biologists turned to investigations of the physical nature of the gene. In the 1940s and early 1950s, experiments pointed to DNA as the portion of chromosomes (and perhaps other nucleoproteins) that held genes. A focus on new model organisms such as viruses and bacteria, along with the discovery of the double helical structure of DNA in 1953, marked the transition to the era of molecular genetics. In the following years, chemists developed techniques for sequencing both nucleic acids and proteins, while many others worked out the relationship between these two forms of biological molecules and discovered the genetic code. The regulation of gene expression became a central issue in the 1960s; by the 1970s gene expression could be controlled and manipulated through genetic engineering. In the last decades of the 20th century, many biologists focused on large-scale genetics projects, such as sequencing entire genomes.
== Pre-Mendel ideas on heredity ==
=== Ancient theories ===
The most influential early theories of heredity were that of Hippocrates and Aristotle. Hippocrates' theory (possibly based on the teachings of Anaxagoras) was similar to Darwin's later ideas on pangenesis, involving heredity material that collects from throughout the body. Aristotle suggested instead that the (nonphysical) form-giving principle of an organism was transmitted through semen (which he considered to be a purified form of blood) and the mother's menstrual blood, which interacted in the womb to direct an organism's early development. For both Hippocrates and Aristotle—and nearly all Western scholars through to the late 19th century—the inheritance of acquired characters was a supposedly well-established fact that any adequate theory of heredity had to explain. At the same time, individual species were taken to have a fixed essence; such inherited changes were merely superficial. The Athenian philosopher Epicurus observed families and proposed the contribution of both males and females of hereditary characters ("sperm atoms"), noticed dominant and recessive types of inheritance and described segregation and independent assortment of "sperm atoms". The Roman poet and philosopher Lucretius describes heredity in his work "De rerum natura".
From this semen, Venus produces a varied variety of characteristics and reproduces ancestral traits of expression, voice or hair; These features, as well as our faces, bodies, and limbs, are also determined by the specific semen of our relatives. Similarly, Marcus Terentius Varro in "Rerum rusticarum libri tres" and Publius Vergilius Maro propose that wasps and bees originate from animals like horses, calves, and donkeys, with wasps coming from horses and bees from calves or donkeys. In 1000 CE, the Arab physician, Abu al-Qasim al-Zahrawi (known as Albucasis in the West) was the first physician to describe clearly the hereditary nature of haemophilia in his Al-Tasrif. In 1140 CE, Judah HaLevi described dominant and recessive genetic traits in The Kuzari.
=== Preformation theory ===
The preformation theory is a developmental biological theory, which was represented in antiquity by the Greek philosopher Anaxagoras. It reappeared in modern times in the 17th century and then prevailed until the 19th century. Another common term at that time was the theory of evolution, although "evolution" (in the sense of development as a pure growth process) had a completely different meaning than today. The preformists assumed that the entire organism was preformed in the sperm (animalkulism) or in the egg (ovism or ovulism) and only had to unfold and grow. This was contrasted by the theory of epigenesis, according to which the structures and organs of an organism only develop in the course of individual development (Ontogeny). Epigenesis had been the dominant opinion since antiquity and into the 17th century, but was then replaced by preformist ideas. Since the 19th century epigenesis was again able to establish itself as a view valid to this day.
=== Plant systematics and hybridisation ===
In the 18th century, with increased knowledge of plant and animal diversity and the accompanying increased focus on taxonomy, new ideas about heredity began to appear. Linnaeus and others (among them Joseph Gottlieb Kölreuter, Carl Friedrich von Gärtner, and Charles Naudin) conducted extensive experiments with hybridisation, especially hybrids between species. Species hybridisers described a wide variety of inheritance phenomena, include hybrid sterility and the high variability of back-crosses. Plant breeders were also developing an array of stable varieties in many important plant species. In the early 19th century, Augustin Sageret established the concept of dominance, recognising that when some plant varieties are crossed, certain characteristics (present in one parent) usually appear in the offspring; he also found that some ancestral characteristics found in neither parent may appear in offspring. However, plant breeders made little attempt to establish a theoretical foundation for their work or to share their knowledge with current work of physiology, although Gartons Agricultural Plant Breeders in England explained their system.