14 lines
1.0 KiB
Markdown
14 lines
1.0 KiB
Markdown
---
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title: "Analytical light scattering"
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chunk: 1/1
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source: "https://en.wikipedia.org/wiki/Analytical_light_scattering"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T10:03:38.039413+00:00"
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instance: "kb-cron"
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---
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Analytical light scattering (ALS), also loosely referred to as SEC-MALS, is the implementation of static light scattering (SLS) and dynamic light scattering (DLS) techniques in an online or flow mode. A typical ALS instrument consists of an HPLC/FPLC chromatography system coupled in-line with appropriate light scattering and refractive index detectors. The advantage of ALS over conventional steady-state light scattering methods is that it allows separation of molecules/macromolecules on a chromatography column prior to analysis with light scattering detectors. Accordingly, ALS enables one to determine hydrodynamic properties of a single monodisperse species as opposed to bulk or average measurements on a sample afforded by conventional light scattering.
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== References == |