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| title | chunk | source | category | tags | date_saved | instance |
|---|---|---|---|---|---|---|
| Open-label trial | 1/1 | https://en.wikipedia.org/wiki/Open-label_trial | reference | science, encyclopedia | 2026-05-05T03:44:27.552355+00:00 | kb-cron |
An open-label trial, or open trial, is a type of clinical trial in which information is not withheld from trial participants. In particular, both the researchers and participants know which treatment is being administered. This contrasts with a double-blinded trial, where information is withheld both from the researchers and the participants to reduce bias. Open-label trials may be appropriate for comparing two similar treatments to determine which is most effective, such as a comparison of different prescription anticoagulants, or possible relief from symptoms of some disorders when a placebo is given. An open-label trial may still be randomized. Open-label trials may also be uncontrolled (without a placebo group), with all participants receiving the same treatment. This would be a single-arm study design.
== References ==