Scrape wikipedia-science: 768 new, 902 updated, 1716 total (kb-cron)
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source: "https://en.wikipedia.org/wiki/Evolution@Home"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T03:24:21.149485+00:00"
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date_saved: "2026-05-05T04:11:54.396386+00:00"
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data/en.wikipedia.org/wiki/FightAIDS@Home-0.md
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data/en.wikipedia.org/wiki/FightAIDS@Home-0.md
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title: "FightAIDS@Home"
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source: "https://en.wikipedia.org/wiki/FightAIDS@Home"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T04:11:55.590840+00:00"
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FightAIDS@Home is a volunteer computing project operated by the Olson Laboratory at The Scripps Research Institute. It runs on internet-connected home computers, and since July 2013 also runs on Android smartphones and tablets. It aims to use biomedical software simulation techniques to search for ways to cure or prevent the spread of HIV/AIDS.
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== Methods ==
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Olson's target is HIV protease, a key molecular machine of the virus that when blocked stops it from maturing. These blockers, known as "protease inhibitors", are thus a way of avoiding the onset of AIDS and prolonging life. The Olson Laboratory is using computational methods to identify new candidate drugs that have the right shape and chemical characteristics to block HIV protease. This general approach is called structure-based drug design, and according to the National Institutes of Health's National Institute of General Medical Sciences, it has already had a dramatic effect on the lives of people living with AIDS.
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FightAIDS@Home makes use of the AutoDock VINA software, which tests how well a particular molecule binds to the HIV-1 protease.
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In October 2015 FightAIDS@Home Phase 2 was launched, using the computationally intensive Binding Energy Distribution Analysis Method (BEDAM) to "more thoroughly evaluate the top candidates from the vast number of results generated in Phase 1".
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== History ==
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It was originally implemented using a distributed computing software infrastructure provided by Entropia. However, since May 2003 FightAIDS@Home has not been associated with Entropia, and on November 21, 2005, the project moved to World Community Grid and the Entropia software was abandoned.
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Scripps Research Institute published its first peer-reviewed scientific paper about the results of FightAIDS@Home on April 21, 2007. This paper explains that the results up to that point will primarily be used to improve the efficiency of future FightAIDS@Home calculations.
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On February 3, 2010, the project announced it found two compounds that make a completely new class of AIDS-fighting drugs possible: "two compounds that act on novel binding sites for an enzyme used by the human immunodeficiency virus (HIV), the virus that causes AIDS. The discovery lays the foundation for the development of a new class of anti-HIV drugs to enhance existing therapies, treat drug-resistant strains of the disease, and slow the evolution of drug resistance in the virus."
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A March 2022 research paper details the results of the screening of over 1.6 million ZINC compounds at World Community Grid. First screened using AutoDock Vina, the top-scoring 500 were then analysed using BEDAM. After further screening, 24 of these were selected to perform thermal shift assays. 2 compounds appear to bind at the HIV-1 Capsid dimmer interface, possibly by occupying a new sub-pocket that has not been exploited by any existing HIV-1 capsid inhibitors.
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== System requirements ==
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The minimum system requirements to run FightAIDS@home are:
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With distributed computing every computer added accelerates the project, while the program has little impact on the performance of the machine where it is installed, as the calculation process can be set to run at minimum priority in the background.
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== Publications ==
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Chang, Max W.; Lindstrom, William; Olson, Arthur J.; Belew, Richard K. (2007). "Analysis of HIV Wild-Type and Mutant Structures via in Silico Docking against Diverse Ligand Libraries" (PDF). J. Chem. Inf. Model. 47 (3): 1258–1262. doi:10.1021/ci700044s. PMID 17447753.
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Perryman, A.; Santiago, D.; Forli, S.; Santos-Martins, D.; Olson, A. (2014), "Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein–ligand binding challenge", Journal of Computer-Aided Molecular Design, 28 (4): 429–441, Bibcode:2014JCAMD..28..429P, doi:10.1007/s10822-014-9709-3, PMC 4053500, PMID 24493410
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== See also ==
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List of volunteer computing projects
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== References ==
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== External links ==
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World Community Grid - Research - FightAIDS@Home
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FightAIDS@Home Archived 2019-10-08 at the Wayback Machine
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World Community Grid Targets AIDS in Giant Research Effort
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HIV-1 Capsid Project Archived 2017-05-11 at the Wayback Machine
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Volunteer computing projects
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title: "Fiocruz Genome Comparison Project"
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source: "https://en.wikipedia.org/wiki/Fiocruz_Genome_Comparison_Project"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T04:11:56.811012+00:00"
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The Fiocruz Genome Comparison Project is a collaborative effort involving Brazil's Oswaldo Cruz Institute and IBM's World Community Grid, designed to produce a database comparing the genes from many genomes with each other using SSEARCH. The program SSEARCH performs a rigorous Smith–Waterman alignment between a protein sequence and another protein sequence, a protein database, a DNA or a DNA library.
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The nature of the computation in the project allows it to easily take advantage of volunteer computing. This, along with the likely humanitarian benefits of the research, has led the World Community Grid (a volunteer computing grid that uses idle computer clock time) to run the Fiocruz project. All products are in the public domain by contract with WCG.
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== Description ==
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The problem is that a very large information body (structural, functional, cross-references, etc.) is attached to protein database entries. Once entered the information is rarely updated or corrected. This annotation of predicted protein function is often incomplete, uses non-standard nomenclature or can be incorrect when cross referenced from previous sometimes incorrectly annotated sequences. Additionally, many proteins composed of several structural and/or functional domains are overlooked by automated systems. The comparative information today is huge when compared to the early days of genomics. A single error is compounded and then made complex.
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The Genome Comparison Project performs a complete pairwise comparison between all predicted protein sequences, obtaining indices used (together with standardized Gene Ontology) as a reference repository for the annotator community. The project provides invaluable data sources for biologists. The sequence similarity comparison program used in the Genome Comparison Project is called SSEARCH. This program mathematically finds best local alignment between sequence pairs, and is a freely available implementation of the Smith–Waterman algorithm.
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SSEARCH's use makes possible a precise annotation, inconsistencies correction, and possible functions assignment to hypothetical proteins of unknown function. Moreover, proteins with multiple domains and functional elements are correctly spotted. Even distant relationships are detected.
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== See also ==
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Comparative genomics
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== Notes ==
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== External links ==
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Genome Comparison Project
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World Community Grid Project
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source: "https://en.wikipedia.org/wiki/FreeHAL"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T03:24:29.207419+00:00"
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source: "https://en.wikipedia.org/wiki/GPUGRID.net"
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category: "reference"
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date_saved: "2026-05-05T03:24:34.200411+00:00"
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source: "https://en.wikipedia.org/wiki/GridRepublic"
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category: "reference"
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date_saved: "2026-05-05T03:24:35.375240+00:00"
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date_saved: "2026-05-05T04:12:01.716639+00:00"
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23
data/en.wikipedia.org/wiki/Gridcoin-0.md
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title: "Gridcoin"
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source: "https://en.wikipedia.org/wiki/Gridcoin"
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category: "reference"
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date_saved: "2026-05-05T04:12:00.566746+00:00"
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---
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Gridcoin (abbreviation: GRC) is a cryptocurrency which rewards volunteer computing performed on the BOINC platform. BOINC was originally developed to support SETI@home, but has also been used for research in other areas.
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Gridcoin was created on October 16, 2013, by Rob Halförd. Initially using the energy-intensive proof of work, as used by Bitcoin, Gridcoin migrated to a proof of stake protocol in 2014, similar to Peercoin, in an attempt to address the environmental impact of cryptocurrency mining.
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An exploit was demonstrated in August 2017 that revealed the email addresses of Gridcoin users and allowed the theft of other users' work. The research team had disclosed the vulnerability to the developers in September 2016, and a patch was released in March 2017 with version 3.5.8.7. However the implementation of the fix introduced other issues.
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The implementation Gridcoin-Research was created as a fork of Bitcoin and Peercoin and is licensed under the MIT License. It uses Qt 5 for its user interface and prebuilt executables of the wallet are distributed for Windows, macOS, and Debian.
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== References ==
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== External links ==
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Official website
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source: "https://en.wikipedia.org/wiki/HashClash"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T03:24:36.616095+00:00"
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source: "https://en.wikipedia.org/wiki/Help_Conquer_Cancer"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T03:24:37.822452+00:00"
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date_saved: "2026-05-05T04:12:04.139358+00:00"
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source: "https://en.wikipedia.org/wiki/Help_Cure_Muscular_Dystrophy"
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category: "reference"
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tags: "science, encyclopedia"
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date_saved: "2026-05-05T03:24:42.553225+00:00"
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date_saved: "2026-05-05T04:12:05.359382+00:00"
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