---
title: "TiHKAL"
chunk: 1/1
source: "https://en.wikipedia.org/wiki/TiHKAL"
category: "reference"
tags: "science, encyclopedia"
date_saved: "2026-05-05T03:34:39.104345+00:00"
instance: "kb-cron"
---

TiHKAL: The Continuation, also known as Tryptamines I Have Known and Loved, is a 1997 book written by Alexander Shulgin and Ann Shulgin. It is about a family of psychoactive drugs known as tryptamines, which includes psychedelics, other hallucinogens, and entactogens. The book has two halves, and the second part of the book contains detailed entries on 55 tryptamines. TiHKAL is a sequel to PiHKAL: A Chemical Love Story (Phenethylamines I Have Known and Loved) (1991).


== Content ==
TiHKAL, much like its predecessor PiHKAL, is divided into two parts. The first part, for which all rights are reserved, begins with a fictionalized autobiography, picking up where the similar section of PiHKAL left off; it then continues with a collection of essays on topics ranging from psychotherapy and the Jungian mind to the prevalence of DMT in nature, ayahuasca and the war on drugs.
The second part of TiHKAL, which may be conditionally distributed for non-commercial reproduction (see § External links, below), is a detailed synthesis manual for 55 tryptamines (many discovered by Alexander Shulgin himself), including their chemical structures, doses, durations, and commentary. It includes entries on compounds including simple tryptamines like dimethyltryptamine (DMT), psilocin, and 5-MeO-DMT, α-alkyltryptamines like α-methyltryptamine (AMT), β-carbolines or harmala alkaloids like harmaline, the iboga alkaloid ibogaine, and lysergamides like LSD. Whereas PiHKAL had 179 entries on phenethylamines, TiHKAL has only 55 entries. Shulgin has made the second part freely available on Erowid while the first part is available only in the printed text.
Members of Shulgin's research who contributed to the experience reports included Shulgin himself, Ann Shulgin, Myron Stolaroff, and Jean Stolaroff, among others.


== Response ==
As with PiHKAL, the Shulgins were motivated to release the synthesis information as a way to protect the public's access to information about psychedelic compounds, a goal Alexander Shulgin has noted many times. Following a raid of his laboratory in 1994 by the United States DEA, Richard Meyer, spokesman for DEA's San Francisco Field Division, stated that "It is our opinion that those books [referring to the previous work, PiHKAL] are pretty much cookbooks on how to make ‘controlled drugs’. Agents tell me that in clandestine labs that they have raided, they have found copies of those books."


== Notable compounds ==
Some compounds in TiHKAL, including dimethyltryptamine (DMT), psilocybin (4-PO-DMT), psilocin (4-HO-DMT), bufotenin (5-HO-DMT), 5-MeO-DMT, α-methyltryptamine (AMT), lysergic acid diethylamide (LSD), harmaline, and ibogaine, are widely known and/or used hallucinogens.


== Tryptamines listed ==

In addition to TiHKAL, Shulgin has also described the properties of psychedelic tryptamines in humans in literature reviews.


== See also ==
Bibliography of Alexander Shulgin
PiHKAL (Phenethylamines I Have Known and Loved) (1991)
The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds (2011)
List of psychedelic literature
Substituted tryptamine
Substituted β-carboline and harmala alkaloid
Azepinoindole and iboga alkaloid
Substituted lysergamide


== References ==


== External links ==
Erowid Online Books: TiHKAL: The Continuation by Alexander & Ann Shulgin
"Shulgin in Spanish" Project – Information on the first complete translation of PiHKAL and TiHKAL into Spanish
TiHKAL • Info: A Visual Index and Map of TiHKAL: The Continuation by Alexander & Ann Shulgin
Transform Press – Publisher of TiHKAL
TiHKAL - Wikipedia Massviews Analysis (Wikipedia Page Views of Individual TiHKAL Entries)