---
title: "History of scientific method"
chunk: 5/11
source: "https://en.wikipedia.org/wiki/History_of_scientific_method"
category: "reference"
tags: "science, encyclopedia"
date_saved: "2026-05-05T03:43:10.599999+00:00"
instance: "kb-cron"
---

=== Renaissance humanism and medicine ===
Aristotle's ideas became a framework for critical debate beginning with absorption of the Aristotelian texts into the university curriculum in the first half of the 13th century. Contributing to this was the success of medieval theologians in reconciling Aristotelian philosophy with Christian theology. Within the sciences, medieval philosophers were not afraid of disagreeing with Aristotle on many specific issues, although their disagreements were stated within the language of Aristotelian philosophy. All medieval natural philosophers were Aristotelians, but "Aristotelianism" had become a somewhat broad and flexible concept.  With the end of Middle Ages, the Renaissance rejection of medieval traditions coupled with an extreme reverence for classical sources led to a recovery of other ancient philosophical traditions, especially the teachings of Plato.  By the 17th century, those who clung dogmatically to Aristotle's teachings were faced with several competing approaches to nature.

The discovery of the Americas at the close of the 15th century showed the scholars of Europe that new discoveries could be found outside of the authoritative works of Aristotle, Pliny, Galen, and other ancient writers.
Galen of Pergamon (129 – c. 200 AD) had studied with four schools in antiquity — Platonists, Aristotelians, Stoics, and Epicureans, and at Alexandria, the center of medicine at the time. In his Methodus Medendi, Galen had synthesized the empirical and dogmatic schools of medicine into his own method, which was preserved by Arab scholars. After the translations from Arabic were critically scrutinized, a backlash occurred and demand arose in Europe for translations of Galen's medical text from the original Greek. Galen's method became very popular in Europe. Thomas Linacre, the teacher of Erasmus, thereupon translated Methodus Medendi from Greek into Latin for a larger audience in 1519. Limbrick 1988 notes that 630 editions, translations, and commentaries on Galen were produced in Europe in the 16th century, eventually eclipsing Arabic medicine there, and peaking in 1560, at the time of the Scientific Revolution.
By the late 15th century, the physician-scholar Niccolò Leoniceno was finding errors in Pliny's Natural History. As a physician, Leoniceno was concerned about these botanical errors propagating to the materia medica on which medicines were based. To counter this, a botanical garden was established at Orto botanico di Padova, University of Padua (in use for teaching by 1546), in order that medical students might have empirical access to the plants of a pharmacopia. Other Renaissance teaching gardens were established, notably by the physician Leonhart Fuchs, one of the founders of botany.

The first printed work devoted to the concept of method is Jodocus Willichius, De methodo omnium artium et disciplinarum informanda opusculum (1550). An Informative Essay on the Method of All Arts and Disciplines (1550)

=== Skepticism as a basis for understanding ===
In 1562 Outlines of Pyrrhonism by the ancient Pyrrhonist philosopher Sextus Empiricus (c. 160–210 AD) was published in a Latin translation (from Greek), quickly placing the arguments of classical skepticism in the European mainstream. These arguments establish seemingly insurmountable challenges for the possibility of certain knowledge.
The skeptic philosopher and physician Francisco Sanches, was led by his medical training at Rome, 1571–73, to search for a true method of knowing (modus sciendi), as nothing clear can be known by the methods of Aristotle and his followers — for example, 1) syllogism fails upon circular reasoning; 2) Aristotle's modal logic was not stated clearly enough for use in medieval times, and remains a research problem to this day. Following the physician Galen's method of medicine, Sanches lists the methods of judgement and experience, which are faulty in the wrong hands, and we are left with the bleak statement That Nothing is Known (1581, in Latin Quod Nihil Scitur). This challenge was taken up by René Descartes in the next generation (1637), but at the least, Sanches warns us that we ought to refrain from the methods, summaries, and commentaries on Aristotle, if we seek scientific knowledge. In this, he is echoed by Francis Bacon who was influenced by another prominent exponent of skepticism, Montaigne; Sanches cites the humanist Juan Luis Vives who sought a better educational system, as well as a statement of human rights as a pathway for improvement of the lot of the poor.
"Sanches develops his scepticism by means of an intellectual critique of Aristotelianism, rather than by an appeal to the history of human stupidity and the variety and contrariety of previous theories." —Popkin 1979, p. 37, as cited by Sanches, Limbrick & Thomson 1988, pp. 24–25

"To work, then; and if you know something, then teach me; I shall be extremely grateful to you. In the meantime, as I prepare to examine Things, I shall raise the question anything is known, and if so, how, in the introductory passages of another book, a book in which I will expound, as far as human frailty allows, the method of knowing. Farewell.
WHAT IS TAUGHT HAS NO MORE STRENGTH THAN IT DERIVES FROM HIM WHO IS TAUGHT.

WHAT?" —Francisco Sanches (1581) Quod Nihil Scitur p. 100
Descartes' famous "Cogito" argument is an attempt to overcome skepticism and reestablish a foundation for certainty but other thinkers responded by revising what the search for knowledge, particularly physical knowledge, might be.

=== Tycho Brahe ===

See History of astronomy § Renaissance and Early Modern Europe, Kepler's laws of planetary motion, and History of optics § Renaissance and Early Modern