---
title: "Design of experiments"
chunk: 1/5
source: "https://en.wikipedia.org/wiki/Design_of_experiments"
category: "reference"
tags: "science, encyclopedia"
date_saved: "2026-05-05T03:14:30.097260+00:00"
instance: "kb-cron"
---

The design of experiments (DOE), also known as experiment design or experimental design, is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation. The term is generally associated with experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments, in which natural conditions that influence the variation are selected for observation.
In its simplest form, an experiment aims at predicting the outcome by introducing a change of the preconditions, which is represented by one or more independent variables, also referred to as "input variables" or "predictor variables." The change in one or more independent variables is generally hypothesized to result in a change in one or more dependent variables, also referred to as "output variables" or "response variables." The experimental design may also identify control variables that must be held constant to prevent external factors from affecting the results. Experimental design involves not only the selection of suitable independent, dependent, and control variables, but planning the delivery of the experiment under statistically optimal conditions given the constraints of available resources.  There are multiple approaches for determining the set of design points (unique combinations of the settings of the independent variables) to be used in the experiment.
Main concerns in experimental design include the establishment of validity, reliability, and replicability. For example, these concerns can be partially addressed by carefully choosing the independent variable, reducing the risk of measurement error, and ensuring that the documentation of the method is sufficiently detailed. Related concerns include achieving appropriate levels of statistical power and sensitivity.
Correctly designed experiments advance knowledge in the natural and social sciences and engineering, with design of experiments methodology recognised as a key tool in the successful implementation of a Quality by Design (QbD) framework. Other applications include marketing and policy making. The study of the design of experiments is an important topic in metascience.

== History ==

=== Statistical experiments, following Charles S. Peirce ===

A theory of statistical inference was developed by Charles S. Peirce in "Illustrations of the Logic of Science" (1877–1878) and  "A Theory of Probable Inference" (1883), two publications that emphasized the importance of randomization-based inference in statistics.

==== Randomized experiments ====

Charles S. Peirce randomly assigned volunteers to a blinded, repeated-measures design to evaluate their ability to discriminate weights.
Peirce's experiment inspired other researchers in psychology and education, which developed a research tradition of randomized experiments in laboratories and specialized textbooks in the 1800s.

==== Optimal designs for regression models ====

Charles S. Peirce also contributed the first English-language publication on an optimal design for regression models in 1876. A pioneering optimal design for polynomial regression was suggested by Gergonne in 1815. In 1918, Kirstine Smith published optimal designs for polynomials of degree six (and less).

=== Sequences of experiments ===

The use of a sequence of experiments, where the design of each may depend on the results of previous experiments, including the possible decision to stop experimenting, is within the scope of sequential analysis, a field that was pioneered by Abraham Wald in the context of sequential tests of statistical hypotheses. Herman Chernoff wrote an overview of optimal sequential designs, while adaptive designs have been surveyed by S. Zacks. One specific type of sequential design is the "two-armed bandit", generalized to the multi-armed bandit, on which early work was done by Herbert Robbins in 1952.

== Fisher's principles ==
A methodology for designing experiments was proposed by Ronald Fisher, in his innovative books: The Arrangement of Field Experiments (1926) and The Design of Experiments (1935).  Much of his pioneering work dealt with agricultural applications of statistical methods.  As a mundane example, he described how to test the lady tasting tea hypothesis, that a certain lady could distinguish by flavour alone whether the milk or the tea was first placed in the cup. These methods have been broadly adapted in biological, psychological, and agricultural research.